Prenatal cocaine alters open-field behavior in young swine

Yucatan minisows received 2 mg/kg cocaine i.v. 4 times daily during the last third of gestation. Their piglets were fostered at birth to paired, unexposed sows with their litters, and studied at age 2 to 9 (young group) and 22 to 29 days (older group). Three to 5 exposed and unexposed piglets of each age group were videotaped together for 30 min on 5 consecutive days in an open-field environment. For each piglet, 41 behaviors were scored, timed, summed and clustered into 9 behavioral categories. With age, and independently of drug exposure, piglets spent more time in ingestion, immobility while alone and play/aggression, and less time in group locomotion. For the first 4 test days, the young exposed piglets spent more time in group immobility and less time in individual locomotion and rooting than their age-matched controls. In contrast, the older exposed and unexposed piglet groups did not differ in any of these behavioral clusters. These results suggest that prenatal cocaine exposure in neonatal swine may transiently affect responses to spatial novelty.