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Meningioangiomatosis: advanced imaging and pathological study of two cases
B Gómez-Ansón1, A Munõz, A Blasco
1Servicio de Radiodiagnóstico (Neurorradiología Infantil), Hospital Universitario Doce de Octubre, Madrid, Spain.
Abstract:
Meningioangiomatosis (MA) is a rare benign intracranial tumour of uncertain pathogenesis, with only 33 cases reported in the literature. Imaging features have been described in 21 cases, only 3 with contrast-enhanced MRI. We present two cases of MA with MRI and/or CT findings and gross, ultrastructural, and immunohistochemical characteristics. MRI is particularly helpful for establishing the origin of the lesion and its anatomical location, while CT shows calcification, if present. The pathological characteristics establish the diagnosis and underline the differences from other entities such as malignant meningioma, one of the most important differential diagnostic considerations.
Insights
Meningioangiomatosis (MA) is a rare intracranial tumor. This study details two MA cases, highlighting MRI and CT imaging findings and pathological characteristics for diagnosis.
Area of Science:
- Neuropathology
- Neuroradiology
- Oncology
Background:
- Meningioangiomatosis (MA) is an exceptionally rare benign intracranial tumor with an unclear origin.
- Fewer than 33 cases have been documented globally, with limited prior imaging data, especially using contrast-enhanced MRI.
Observation:
- This report presents two new cases of meningioangiomatosis.
- Detailed neuroimaging findings from MRI and CT scans are provided for both cases.
- Gross, ultrastructural, and immunohistochemical analyses were performed to characterize the lesions.
Findings:
- MRI proved valuable in pinpointing the lesion's origin and anatomical position.
- CT imaging effectively identified calcifications within the tumor.
- Pathological examination confirmed the diagnosis and differentiated MA from other intracranial tumors, notably malignant meningioma.
Implications:
- Accurate diagnosis of meningioangiomatosis relies on integrating imaging and pathological findings.
- Distinguishing MA from malignant meningioma is crucial for appropriate patient management.
- Further research into MA pathogenesis and optimal diagnostic strategies is warranted.