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Resistance to antivirals

D S Laufer¹, S E Starr

¹Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania, USA.

Pediatric Clinics of North America

|June 1, 1995

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Viral resistance to antiviral drugs is a growing concern for HIV and other viruses. This review covers resistance mechanisms, clinical impacts, and alternative treatments for resistant viral infections.

Area of Science:

Virology
Infectious Diseases
Pharmacology

Background:

Antiviral resistance is a significant challenge in managing viral infections.
The emergence of drug-resistant strains necessitates ongoing research and treatment strategies.

Purpose of the Study:

To review the mechanisms and clinical aspects of antiviral resistance.
To discuss alternative therapies for infections caused by resistant viral strains.

Main Methods:

Literature review of antiviral resistance mechanisms.
Analysis of clinical correlates of resistance.
Identification of alternative drugs for resistant viral infections.

Main Results:

Viral resistance mechanisms vary across different viruses.

Related Experiment Videos

Clinical outcomes are affected by antiviral resistance.

Alternative drugs offer treatment options for resistant strains.

Conclusions:

Understanding antiviral resistance is crucial for effective treatment.
Development of alternative therapies is essential for managing resistant viral infections.
This review provides insights into managing resistant HIV, HSV, CMV, VZV, and Influenza A.