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Resistance to antifungal agents
1Department of Pediatrics, University of Minnesota, Minneapolis, USA.
Pediatric Clinics of North America
|June 1, 1995
Summary
Antifungal resistance is a growing concern in immunocompromised patients due to increased infections. New therapies are urgently needed to combat resistant fungal pathogens.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Increased incidence of Acquired Immunodeficiency Syndrome (AIDS) and immunocompromised states leads to fungal infections.
- Widespread use of antifungal agents has resulted in a significant rise in antifungal resistance.
- Antifungal resistance is a clinically significant and increasingly common problem.
Purpose of the Study:
- To highlight the growing issue of antifungal resistance.
- To emphasize the need for vigilance and new therapeutic strategies.
- To discuss potential novel approaches to combat resistant fungal infections.
Main Methods:
- Review of current clinical landscape regarding fungal infections and resistance.
- Discussion of implications of antimicrobial resistance principles in fungal infections.
- Exploration of emerging therapeutic strategies.
Main Results:
- Antifungal resistance is prevalent and clinically important.
- Prolonged use of antifungal agents selects for resistant organisms.
- Novel therapeutic strategies are under development.
Conclusions:
- Vigilance for antifungal resistance is crucial.
- New antifungal agents and therapeutic strategies are essential.
- Inhibiting fungal colonization and augmenting host defenses are promising avenues.