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Central precocious puberty: evaluation by neuroimaging

L Kornreich1, G Horev, S Blaser

  • 1Department of Pediatric Imaging, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva.

Pediatric Radiology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Central precocious puberty in children can present with abnormal brain findings. Magnetic resonance imaging (MRI) is recommended for investigating this condition.

Area of Science:

  • Pediatric Endocrinology
  • Neuroradiology
  • Child Neurology

Background:

  • Central precocious puberty (CPP) involves early onset of puberty due to central nervous system activation.
  • Intracranial abnormalities are increasingly recognized as potential underlying causes of CPP.
  • Accurate diagnostic imaging is crucial for identifying these pathologies.

Purpose of the Study:

  • To determine the frequency of abnormal intracranial findings in children diagnosed with CPP.
  • To compare the diagnostic utility of different neuroimaging techniques in evaluating CPP.
  • To establish guidelines for optimal neuroimaging in pediatric CPP cases.

Main Methods:

  • A cohort of 62 children (51 girls, 11 boys) with CPP underwent brain imaging.
  • Computerized tomography (CT) and/or magnetic resonance imaging (MRI) were utilized.

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  • Clinical data and imaging results were correlated to assess findings.

    • Main Results:

    • Eighteen out of 62 children (29%) exhibited intracranial pathologies.
    • Common findings included hamartoma of the tuber cinereum (8 cases) and parenchymal loss (3 cases).
    • Other identified lesions involved the hypothalamic-chiasmatic region, corpus callosum, and suprasellar/pineal cysts.

    Conclusions:

    • A significant proportion of children with CPP present with identifiable intracranial abnormalities.
    • Magnetic resonance imaging (MRI) demonstrated superior efficacy in detecting these lesions compared to CT.
    • The study recommends MRI as the primary imaging modality for the etiological investigation of central precocious puberty in children.