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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

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Viral upper respiratory infections

J P Engel1

  • 1Department of Medicine, East Carolina University School of Medicine, Greenville, NC 27858, USA.

Seminars in Respiratory Infections
|March 1, 1995
PubMed

Insights

The common cold, a viral upper respiratory infection, is a frequent illness caused by several virus families. This review covers cold virology, pathogenesis, immunology, and treatment options.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Viral upper respiratory infections, or the common cold, are the most prevalent human illnesses.
  • This acute, mild catarrhal illness typically presents as nasopharyngitis lasting 5–7 days.
  • Key viral culprits include Picornaviridae, Coronaviridae, Paramyxoviridae, Orthomyxoviridae, and Adenoviridae.

Purpose of the Study:

  • To review the fundamental virology, pathogenesis, and immunology of common cold infections.
  • To discuss current and emerging treatment and prevention strategies for the common cold.

Main Methods:

  • Literature review focusing on viral upper respiratory infections.
  • Synthesis of information on common cold etiology, disease mechanisms, and immune responses.
  • Analysis of existing and prospective therapeutic and prophylactic interventions.

Main Results:

  • Common colds are caused by a diverse range of RNA and DNA viruses.
  • Understanding viral mechanisms and host immune responses is crucial for management.
  • Various treatment and prevention modalities exist, with ongoing research for improved options.

Conclusions:

  • The common cold remains a significant public health concern due to its high incidence.
  • Further research into viral pathogenesis and immunology can lead to more effective treatments.
  • Integrated approaches to prevention and treatment are essential for managing this widespread infection.

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