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Processing and secretion of Alzheimer's disease amyloid precursor protein
K Kinbara1, H Kitagaki, T Kinouchi
1Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
The Tohoku Journal of Experimental Medicine
|November 1, 1994
Abstract:
We studied in vivo expression and in vitro secretion of the Alzheimer's disease amyloid precursor protein (APP). The results indicate that secretion of APP is mediated by PKC and the initial step of the processing may occur in the acidic secretory granules of the glial cells. Our results suggest that a metabolic switch of APP in neural cells is critical in amyloid deposition.