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Outcome in familial subarachnoid hemorrhage
J E Bromberg1, G J Rinkel, A Algra
1University Department of Neurology, Utrecht, The Netherlands.
Stroke
|June 1, 1995
Summary
Patients with familial subarachnoid hemorrhage (SAH) face a higher risk of poor outcomes compared to those with sporadic SAH. This finding supports screening family members at risk for this condition.
Area of Science:
- Neurology
- Genetics
- Public Health
Background:
- Familial subarachnoid hemorrhage (SAH) is a significant factor in managing asymptomatic aneurysms.
- The outcome for familial SAH is often overlooked when considering screening and treatment in at-risk families.
Purpose of the Study:
- To evaluate the outcome of subarachnoid hemorrhage in patients with a family history of the condition.
- To compare the outcomes of familial SAH with sporadic SAH to inform screening strategies.
Main Methods:
- A prospective hospital-based study compared patients with familial SAH (at least one first-degree relative with SAH) to those with sporadic SAH (no SAH in first- or second-degree relatives).
- Outcomes were categorized as independence, dependence, or death, with poor outcome defined as death or dependence.
Main Results:
- 52% of patients with familial SAH experienced a poor outcome, compared to 37% with sporadic SAH.
- The adjusted odds ratio for poor outcome in familial SAH was 2.5 (95% CI, 1.0 to 6.0; P = .04).
- The study suggests the risk may be underestimated due to strict patient selection.
Conclusions:
- Patients with familial SAH exhibit an increased risk of poor outcomes.
- These findings advocate for the screening of unaffected first-degree relatives of individuals with familial SAH.