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[Clinical significance of the cardiovascular risk factor fibrinogen in secondary prevention]

D Baller1, U Gleichmann, E Miche

  • 1Herz- und Diabeteszentrum NRW, Kardiologische Klinik, Bad Oeynhausen.

Versicherungsmedizin
|April 1, 1995
PubMed

Insights

High plasma fibrinogen levels are a significant cardiovascular risk factor, increasing the likelihood of heart attack and stroke. Lowering fibrinogen through smoking cessation and lifestyle changes can reduce this risk.

Area of Science:

  • Cardiovascular Medicine
  • Hematology

Context:

  • Epidemiological studies identify plasma fibrinogen as a key cardiovascular risk factor.
  • Clinical research links fibrinogen levels to the severity of coronary heart disease.

Purpose:

  • To elucidate the role of plasma fibrinogen in cardiovascular disease pathogenesis.
  • To explore mechanisms linking fibrinogen to thrombosis and atherogenesis.
  • To review methods for reducing elevated fibrinogen levels.

Summary:

  • Elevated plasma fibrinogen (over 300-350 mg/dl) is an independent risk factor for myocardial infarction and stroke.
  • Fibrinogen impacts blood viscosity, platelet aggregation, and coagulation, promoting a hypercoagulable state.
  • It also contributes to atherogenesis by influencing smooth muscle cell proliferation and migration.

Impact:

  • Identifies smoking as a major determinant of fibrinogen levels, emphasizing smoking cessation for risk reduction.
  • Highlights lifestyle modifications like weight reduction and physical activity.
  • Discusses pharmacological interventions including fibrates, low-dose Urokinase, and LDL-apheresis for managing fibrinogen levels.

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