Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tooth agenesis in Down syndrome

B G Russell¹, I Kjaer

¹Copenhagen County Hospital for Handicapped Children, Vangedehuse, Gentofte, Denmark.

American Journal of Medical Genetics

|February 13, 1995

Summary

Individuals with Down syndrome exhibit tooth agenesis 10 times more frequently than the general population, with specific patterns observed in the mandible and maxilla, particularly in males.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Eruptive movements of ectopic permanent mandibular canines: a case series study based on serial orthopantomograms from ten children with unilateral ectopia and six children with bilateral ectopia.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2025

Same author

The ectopic mandibular canines can start tooth formation in three different locations: a case series study based on single orthopantomograms from 47 individuals.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2024

Same author

The location of the permanent mandibular canine as identified in orthopantomograms from children younger than 5 years of age: a case series study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2023

Same author

Abnormal premolar eruption: classification, aetiology, and treatment based on a case series study.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021

Same author

Localised scleroderma en coup de sabre affecting the skin, dentition and bone tissue within craniofacial neural crest fields. Clinical and radiographic study of six patients.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2019

Same author

Dental and craniofacial findings in 91 individuals with agenesis of permanent maxillary canines.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2017

Area of Science:

Genetics
Dentistry
Human Biology

Background:

Tooth agenesis is a common dental anomaly.
Down syndrome (trisomy 21) is associated with various developmental abnormalities.
Previous studies have indicated dental anomalies in individuals with Down syndrome.

Purpose of the Study:

To investigate the frequency and specific patterns of tooth agenesis in a Danish population with Down syndrome.
To compare agenesis rates between individuals with Down syndrome and the general population.
To explore potential etiological factors related to tooth agenesis in Down syndrome.

Main Methods:

A case-control study comparing a Danish population with Down syndrome to a normal Danish population.
Analysis of tooth agenesis frequency, laterality, and specific tooth types affected.
Statistical comparison of agenesis patterns between the groups.

Main Results:

Individuals with Down syndrome showed a 10-fold greater occurrence of tooth agenesis compared to the general population.
Agenesis was more frequent in males than females and more common in the mandible than the maxilla, predominantly on the left side.
Significant differences were noted in agenesis of mandibular central incisors, maxillary lateral incisors and second premolars, and mandibular second premolars.

Conclusions:

The pattern of tooth agenesis in Down syndrome may be linked to peripheral nervous system and abnormal cartilaginous tissue development.
Dentition anomalies, including agenesis, can serve as indicators for evaluating pathogenetic aspects of aneuploidy conditions like Down syndrome.

Related Experiment Videos