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Related Experiment Videos

P-glycoprotein and pharmacokinetics

D Levêque1, F Jehl

  • 1Institut de Bactériologie de la Faculté de Médecine, Université Louis-Pasteur, Strasbourg, France.

Anticancer Research
|March 1, 1995
PubMed
Summary
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P-glycoprotein (P-gp) acts as a pump, expelling anticancer drugs from tumor cells and reducing their effectiveness. This review details how P-gp influences drug absorption, distribution, and elimination in the body.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cell Biology

Background:

  • P-glycoprotein (P-gp) is a transmembrane protein linked to multidrug resistance in cancer chemotherapy.
  • P-gp functions as an energy-dependent efflux pump, reducing intracellular drug accumulation and activity.

Purpose of the Study:

  • To review the current understanding of P-gp's role in drug disposition.
  • To explore the impact of P-gp on pharmacokinetic processes.

Main Methods:

  • Literature review of studies investigating P-gp.
  • Analysis of P-gp expression in tumor and normal tissues.
  • Examination of P-gp's involvement in drug absorption, distribution, and elimination.

Main Results:

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  • P-gp is found in various tumor cells and normal tissues, particularly those involved in xenobiotic metabolism.
  • P-gp's physiological functions are not fully understood but are implicated in pharmacokinetics.
  • Evidence suggests P-gp significantly affects how drugs are absorbed, distributed, and eliminated.

    • Conclusions:

    • P-glycoprotein plays a critical role in the disposition of drugs, influencing their pharmacokinetic profiles.
    • Understanding P-gp's impact is crucial for optimizing anticancer drug efficacy and managing drug interactions.