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Misuse of veterinary phenylbutazone
1Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, USA.
Archives of Internal Medicine
|June 12, 1995
Summary
Phenylbutazone (PBZ), a potent NSAID, is linked to severe side effects like aplastic anemia in humans. Veterinarian-grade PBZ caused gastric ulcers and kidney issues in a horse trainer, highlighting a pattern of illicit use.
Area of Science:
- Veterinary Medicine
- Human Toxicology
- Pharmacology
Background:
- Phenylbutazone (PBZ) is a nonsteroidal anti-inflammatory drug (NSAID) historically used for arthritis.
- PBZ was withdrawn from human use due to severe adverse effects, including aplastic anemia.
- Veterinary formulations of PBZ remain available, posing potential risks.
Observation:
- A case study of a horse trainer who developed gastric ulcers and renal insufficiency.
- The trainer's symptoms were attributed to the illicit consumption of veterinary phenylbutazone.
- Literature review indicates a pattern of phenylbutazone abuse among individuals working with animals.
Findings:
- Illicit use of veterinary phenylbutazone can lead to serious gastrointestinal and renal complications in humans.
- Individuals in close contact with animals may be at higher risk for PBZ abuse.
- Adverse events associated with PBZ consumption are significant and potentially life-threatening.
Implications:
- Clinicians should consider illicit phenylbutazone use in patients presenting with unexplained gastric or renal issues, especially those working with animals.
- Increased awareness and screening for veterinary drug misuse are crucial in occupational health.
- This case underscores the importance of monitoring and controlling access to potent veterinary medications.