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[Pyrido(3,2-e)(1,4)diazepines--synthesis and testing of anti-HIV-1 activity]
K Görlitzer1, C Wilpert, H Rübsamen-Waigmann
1Institut für Pharmazeutische Chemie, Technischen Universität Braunschweig.
Archiv Der Pharmazie
|March 1, 1995
Abstract:
Starting from the commercially available 6-methyl-2-pyridylamine (1) the pyrido[3,2-e][1,4]diazepine 14a was synthesized in 12 steps with 7% total yield. 14a, the N-methyl derivative 14b, the thiolactam 15a, the amidine 16, and the 1,2,4-triazole 17 were tested for anti-HIV-1-activity. None of the compounds tested possesses antiviral activity comparable to that of zidovudine (3'-azido-3'-desoxythymidine = AZT).