Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of a cyclodextrin production process using specific adsorbents

M Okabe1, Y Tsuchiyama, R Okamoto

  • 1Shizuoka University, Japan.

Bioprocess Technology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetics of soybean oil consumption and cephamycin C production in culture of Streptomyces sp. using mineral support.

Journal of bioscience and bioengineering·2005
Same author

Image analysis of morphological change during arachidonic acid production by Mortierella alpina 1S-4.

Journal of bioscience and bioengineering·2005
Same author

Visualization of a recombinant gene protein in the baculovirus expression vector system using confocal scanning laser microscopy.

Journal of bioscience and bioengineering·2005
Same author

Effect of soybean oil on oxygen transfer in the production of tetracycline with an airlift bioreactor.

Journal of bioscience and bioengineering·2005
Same author

Effect of nitrogen source on mycelial morphology and arachidonic acid production in cultures of Mortierella alpina.

Journal of bioscience and bioengineering·2005
Same author

Enhancement of epsilon-polylysine production by Streptomyces albulus strain 410 using pH control.

Journal of bioscience and bioengineering·2005
Same journal

Design, formulation, and optimization of media.

Bioprocess technology·1995
Same journal

Sterilization and containment.

Bioprocess technology·1995
Same journal

Immobilized animal cell bioreactors.

Bioprocess technology·1995
Same journal

Immobilized microorganism bioreactors.

Bioprocess technology·1995
Same journal

Stirred tank bioreactors.

Bioprocess technology·1995
Same journal

Fundamentals of bioreactor design.

Bioprocess technology·1995
See all related articles

Chemists developed novel adsorbents for efficient alpha- and beta-cyclodextrin (CD) production. These adsorbents significantly improve alpha-CD yield and purity, offering a scalable, solvent-free industrial purification method.

Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Materials Science

Background:

  • Cyclodextrins (CDs) are crucial in various industries, but their efficient production and purification remain challenging.
  • Current methods for CD production often involve complex processes and may require organic solvents, limiting industrial scalability.
  • Development of selective adsorbents is key to improving CD manufacturing.

Purpose of the Study:

  • To synthesize and screen novel adsorbents for selective production of alpha- and beta-cyclodextrins (CDs).
  • To develop an efficient, scalable, and solvent-free process for alpha-CD production using the optimized adsorbent.
  • To explore the potential for industrial-scale production of other CDs, such as gamma-CD.

Main Methods:

  • Chemical synthesis of novel adsorbents comprising ligand, spacer, and support components.

Related Experiment Videos

  • Two-stage screening to identify optimal adsorbents for alpha-CD and beta-CD.
  • Application of selective adsorbents in a closed system for alpha-CD production using CGTase.
  • Comparison of yields and purity in batch vs. adsorbent-assisted processes.

    • Main Results:

    • Stearic acid and cyclohexanepropanamide-n-caproic acid identified as optimal ligands for alpha-CD and beta-CD, respectively.
    • Adsorbents derived from carboxylic acids and Chitosan beads demonstrated near 100% selectivity and high capacity.
    • Novel process achieved a 22.3% yield and 57.4% fraction of alpha-CD, significantly outperforming the batch system (10.8% yield, 24% fraction).
    • The process is suitable for large-scale alpha-CD production without organic solvents.

    Conclusions:

    • Novel adsorbents offer high selectivity and capacity for cost-effective industrial production and purification of CDs.
    • The developed adsorbent-based process significantly enhances alpha-CD yield and purity, enabling solvent-free manufacturing.
    • This approach paves the way for the industrial production of various CDs, including gamma-CD.