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Propranolol in hypertension: a dose-response study

D B Galloway, S C Glover, W G Hendry

    British Medical Journal
    |July 17, 1976
    PubMed
    Summary
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    Propranolol at 120 mg/day and 240 mg/day effectively reduced blood pressure in hypertensive patients. Lower doses of propranolol (60 mg/day) showed no significant benefit over placebo.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Hypertension is a prevalent cardiovascular condition requiring effective pharmacologic management.
    • Beta-blockers, such as propranolol, are commonly used antihypertensive agents.
    • Understanding dose-response relationships is crucial for optimizing treatment efficacy and safety.

    Purpose of the Study:

    • To evaluate the efficacy and safety of different propranolol dosages in treating hypertension.
    • To compare the blood pressure-lowering effects of propranolol against a placebo.
    • To assess the impact of propranolol on adverse reactions and patient weight.

    Main Methods:

    • A double-blind, randomized crossover trial was conducted.
    • Twenty-four hypertensive outpatients participated in the study.

    Related Experiment Videos

  • Patients received propranolol (60 mg/day, 120 mg/day, 240 mg/day) and placebo for four weeks each.

    • Main Results:

    • Propranolol 60 mg/day did not significantly reduce blood pressure compared to placebo.
    • Both propranolol 120 mg/day and 240 mg/day significantly lowered lying blood pressure by approximately 20/10 mm Hg.
    • No significant differences were observed in weight changes or adverse reactions across all treatment groups.

    Conclusions:

    • Higher doses of propranolol (120 mg/day and 240 mg/day) are effective in reducing blood pressure in hypertensive patients.
    • The 60 mg/day dose of propranolol is not superior to placebo for blood pressure control.
    • Propranolol demonstrated a favorable safety profile with no significant adverse effects or weight gain noted at the studied doses.