Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell adhesion molecules during Xenopus myogenesis

G Levi1

  • 1Department of Cell Differentiation, I.S.T., Genova, Italy.

Cytotechnology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Highly Ionizing Particles in pp Collisions during LHC Run 2 Using the Full MoEDAL Detector.

Physical review letters·2025
Same author

Erratum: First Search for Dyons with the Full MoEDAL Trapping Detector in 13 TeV pp Collisions [Phys. Rev. Lett. 126, 071801 (2021)].

Physical review letters·2024
Same author

MoEDAL Search in the CMS Beam Pipe for Magnetic Monopoles Produced via the Schwinger Effect.

Physical review letters·2024
Same author

Diagnostic role of internal mammary lymph node involvement in tuberculous pleurisy: a multicenter study.

Pulmonology·2022
Same author

Search for magnetic monopoles produced via the Schwinger mechanism.

Nature·2022
Same author

Phenotyping OSAH patients during wakefulness.

Sleep & breathing = Schlaf & Atmung·2022

Cell adhesion molecules like N-CAM and EP-cadherin are crucial for muscle development in Xenopus. Their distinct expression patterns guide myoblast fusion and differentiation during larval stages.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Background:

  • Muscle development involves critical cell recognition events, including myoblast fusion and synaptogenesis.
  • Cell surface adhesion receptors are essential for regulating these complex developmental processes.

Purpose of the Study:

  • To investigate the expression patterns of three cell adhesion molecules: N-CAM, N-cadherin, and EP-cadherin.
  • To elucidate the specific roles of these molecules in Xenopus larval muscle development and myogenesis.

Main Methods:

  • Analysis of gene expression during Xenopus larval muscle development.
  • Immunohistochemical localization of N-CAM, N-cadherin, and EP-cadherin in developing muscle tissues.

Main Results:

Related Experiment Videos

  • N-CAM expression is high in primary myoblasts and decreases in myotubes, suggesting a role in primary myoblast fusion.
  • EP-cadherin is found in both myoblasts and myotubes, indicating a potential role in secondary myoblast fusion.
  • N-cadherin expression is detected much later in muscle differentiation.

Conclusions:

  • Differential expression of N-CAM, EP-cadherin, and N-cadherin highlights their specific functions in myogenesis.
  • These cell adhesion molecules play distinct, sequential roles in orchestrating muscle development in Xenopus larvae.