Related Experiment Video
Updated: Aug 19, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Genetic engineering of Streptomyces to create hybrid antibiotics
1Genetics Department, John Innes Institute, John Innes Centre, Norwich, UK.
Abstract:
Over the past year, dramatic developments in the technology for isolating and manipulating genes for polyketide synthases have been reported. Significant progress has been made in understanding the mechanisms by which these complex enzymes generate the carbon chains of the polyketides, a highly versatile class of natural products. With the demonstration of the production of novel metabolites by synthase engineering, the stage is excitingly set for rationally manipulating synthase 'programming' to generate tailor-made carbon chains.
Related Concept Videos
Antibiotic Selection
Plant Breeding and Biotechnology
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Bioreactor Controls-III
Production of Antibiotics
Production of Pharmaceuticals

