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Glycosylation

C E Warren1

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

Current Opinion in Biotechnology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Advancements in glycobiology are crucial for realizing the potential of glycoprotein therapeutics. Recent progress in understanding glycan biosynthesis, analysis, structure-function, and manufacturing is paving the way for new treatments.

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Area of Science:

  • Glycobiology
  • Biotechnology
  • Pharmaceutical Sciences

Background:

  • Most candidate recombinant therapeutics are glycoproteins, requiring specific carbohydrate structures for efficacy.
  • Realizing the full potential of these therapeutics necessitates advancements in key areas of glycobiology.

Purpose of the Study:

  • To highlight significant progress in four critical areas of glycobiology relevant to glycoprotein therapeutics.
  • To underscore the importance of these advancements for the development and manufacturing of effective protein-based drugs.

Main Methods:

  • Review of recent developments in glycan biosynthesis and regulation.
  • Assessment of progress in rapid and sensitive oligosaccharide analytical techniques.
  • Examination of structure-function relationship determinations for protein-linked carbohydrates.

Related Experiment Videos

  • Evaluation of advancements in manufacturing systems for controllable and consistent glycosylation.

    • Main Results:

    • Significant progress has been observed across all four key areas of glycobiology.
    • Glycosylation-engineered glucocerebrosidase has been approved for clinical use in Gaucher's disease replacement therapy, exemplifying these advancements.

    Conclusions:

    • Continued progress in glycobiology is essential for the successful development of glycoprotein therapeutics.
    • The successful clinical application of engineered glycoproteins demonstrates the value of these scientific advancements.