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Engineering of cell adhesive immunoglobulin G by grafting the Arg-Gly-Asp cell adhesive signal
K Hashino1, I Kato, Y Kurosawa
1Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 1, 1994
Abstract:
A new artificial cell adhesive protein was engineered by grafting the Arg-Gly-Asp (RGD) sequence, the minimal recognition signal of fibronectin for interaction with integrin, to immunoglobulin G (IgG) by in vitro mutagenesis. The mutagenized protein showed cell adhesive activity on baby hamster kidney (BHK) cells.