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Related Experiment Videos

A novel membrane bioreactor for microbial growth

S Beeton1, B J Bellhouse, C J Knowles

  • 1Department of Applied Biology, University of Central Lancashire, Preston, UK.

Applied Microbiology and Biotechnology
|February 1, 1994
PubMed
Summary

This study demonstrates a novel membrane bioreactor effectively supports Pseudomonas aeruginosa growth, showing enhanced oxygen mass transfer. The bioreactor also facilitated metabolite production and biotransformation, highlighting its biotechnological potential.

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Microbial Physiology
  • Bioprocess Engineering

Background:

  • Membrane bioreactors (MBRs) are crucial for microbial cultivation and bioprocessing.
  • Optimizing gas transfer, particularly oxygen, is vital for aerobic microbial growth.
  • Previous studies indicated potential for MBRs in enhancing gas O2 mass transfer.

Purpose of the Study:

  • To evaluate a novel membrane bioreactor for Pseudomonas aeruginosa growth.
  • To assess the impact of bioreactor size and membrane configuration on microbial growth and gas transfer.
  • To explore the bioreactor's capability for secondary metabolite production and biotransformation.

Main Methods:

  • Cultivation of Pseudomonas aeruginosa in a novel membrane bioreactor with varying configurations.

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  • Measurement of initial growth rates and assessment of oxygen mass transfer.
  • Demonstration of secondary metabolite production by Pseudomonas sp.
  • Bioreactor application for nitrile biotransformation by Nocardia rhodochrous.

    • Main Results:

    • The novel membrane bioreactor readily supported Pseudomonas aeruginosa growth.
    • Dimpled membrane configurations showed enhanced oxygen (O2) mass transfer compared to flat membranes.
    • Successful production of a secondary metabolite was achieved.
    • Efficient biotransformation of a nitrile by Nocardia rhodochrous with product removal via membrane.

    Conclusions:

    • The novel membrane bioreactor is effective for aerobic bacterial cultivation and enhances O2 mass transfer.
    • The bioreactor demonstrates versatility for microbial metabolite production and biotransformation processes.
    • This technology holds significant potential for various applications in biotechnology and bioprocessing.