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Atomic force microscopy and scanning tunnelling microscopy: refining techniques for studying biomolecules

C J Roberts1, P M Williams, M C Davies

  • 1Department of Pharmaceutical Sciences, University of Nottingham, UK.

Trends in Biotechnology
|April 1, 1994
PubMed
Summary
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Scanning tunnelling and atomic force microscopy enable real-time, nanometre-scale imaging of biological samples in water. These advanced biophysical tools are increasingly used in biotechnology for detailed molecular analysis.

Area of Science:

  • Biophysics
  • Nanotechnology
  • Biotechnology

Background:

  • Scanning tunnelling microscopy (STM) and atomic force microscopy (AFM) provide high-resolution imaging capabilities.
  • These techniques offer the potential for real-time analysis of biological structures.
  • Establishing STM and AFM as routine biophysical tools is an active area of research.

Purpose of the Study:

  • To review recent progress in the biotechnological applications of STM and AFM.
  • To highlight specific examples of how these microscopy techniques are used in analysis.
  • To showcase the potential of these methods in understanding biomolecules and biosurfaces.

Main Methods:

  • Utilizing scanning tunnelling microscopy (STM) for nanoscale imaging.
  • Employing atomic force microscopy (AFM) for surface analysis.

Related Experiment Videos

  • Operating microscopes under physiological conditions to mimic biological environments.

    • Main Results:

    • Demonstrated real-time, nanometre-scale imaging of biomolecules.
    • Showcased successful applications in various biotechnological fields.
    • Highlighted the utility of STM and AFM in analyzing biosurfaces.

    Conclusions:

    • STM and AFM are powerful tools for biophysical research.
    • These techniques are becoming routine in biotechnology.
    • Further development promises expanded applications in molecular and surface analysis.