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Enhancement of mutagenic activity of 9-aminoacridine by introducing a nitro group into the molecule
1Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Bioscience, Biotechnology, and Biochemistry
|August 1, 1994
Abstract:
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.