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Production of an isonitrile antibiotic by an UV-induced mutant of Trichoderma harzianum
J L Faull1, K A Graeme-Cook, B L Pilkington
1Department of Biology, Birkbeck College, University of London, U.K.
Phytochemistry
|July 1, 1994
Abstract:
Production of the antibiotic, homothallin II, by a UV-induced mutant strain of Trichoderma harzianum is reported, the wild-type parent of which was not an isonitrile antibiotic-producer. The compound has broad antibiotic activity against Oomycete, Ascomycete and Basidiomycete fungi, and both Gram-positive and -negative bacteria. The significance of the induction of homothallin II is discussed.