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Triterpene saponins from Myrsine pellucida
C Lavaud1, G Massiot, J B Barrera
1Laboratoire de Pharmacognosie, Associé au CNRS-URA 492, Faculté de Pharmacie, Reims, France.
Phytochemistry
|December 1, 1994
Summary
Phytochemical analysis of Myrisine pellucida stem bark yielded quercitol, five saponins, and a novel stigmasterol derivative. Two of the isolated saponins are new chemical entities, with structures elucidated by spectroscopic methods.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Myrisine pellucida is a plant species with potential medicinal properties.
- The chemical constituents of M. pellucida, particularly from its stem bark, have not been extensively studied.
- Natural products often serve as a source for novel therapeutic agents.
Purpose of the Study:
- To isolate and characterize chemical compounds from the stem bark of Myrisine pellucida.
- To identify new compounds and report previously undescribed constituents for this plant species.
- To determine the structures of isolated compounds using advanced spectroscopic techniques.
Main Methods:
- Extraction of secondary metabolites from Myrisine pellucida stem bark.
- Chromatographic techniques for compound isolation (e.g., column chromatography).
- Spectroscopic analysis including 1H NMR, 13C NMR, and mass spectrometry for structure elucidation.
Main Results:
- Quercitol, five saponins, and 3-O-(6'-O-palmitoyl) beta-D-glucopyranosyl stigmasterol were isolated.
- Two novel saponins, cyclamiretin A and cyclamiretin D glycosides, were identified.
- The structures of all isolated compounds were determined, with several being reported for the first time in this plant.
Conclusions:
- The stem bark of Myrisine pellucida is a rich source of diverse phytochemicals.
- The discovery of new saponins highlights the potential of this plant for novel compound isolation.
- Further investigation into the biological activities of these isolated compounds is warranted.