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Insulin-stimulated polypeptide chain elongation in the soleus muscle of mice
F Yoshizawa1, A Tonouchi, Y Miura
1Department of Applied Biological Science, Tokyo Noko University, Japan.
Bioscience, Biotechnology, and Biochemistry
|February 1, 1995
Abstract:
The effect of insulin on polypeptide chain elongation was examined in soleus muscles isolated from 18 hour-fasted mice. Treatment with insulin for 1 hour increased the elongation rate, which was estimated by the half-transit time. This suggests that insulin stimulated protein synthesis by modifying the elongation rate in addition to the initiation rate.