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Synthesis and antihypertensive activity evaluation of indole derivatives N-acetamido substituted
S Grasso1, C Molica, A M Monforte
1Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|February 1, 1995
Abstract:
The synthesis of a series of 1-(alkyl- or aryl-aminocarbonylmethyl)-2-methyl- or 2-phenyl-indoles are described. All compounds were tested for antihypertensive activity on spontaneously hypertensive rats (SHR) and some of them showed a significant reduction of the arterial pressure.