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Metabolic approach for regulation of IL-1 beta in vivo

T Yang1, X Zhu, B Shen

  • 1General Hospital of Beijing Military Region, China.

Science in China. Series B, Chemistry, Life Sciences & Earth Sciences
|March 1, 1995
PubMed

IL-1 beta, the autoantibodies to IL-1 beta and IL-1 beta-containing immune complex in pleural effusion and cerebrospinal fluid were detected using anti-recombinant human IL-1 beta monoclonal antibody. The results indicate that IL-1 beta is detectable in some cases, and the amounts decrease gradually with the chemotherapy following the autoantibodies and the specific detectable immune complex. These autoantibodies may have a feedback effect, inhibiting the IL-1 beta activity, and forming the immune complex to speed the clearance of activated IL-1 beta.

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