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15-hydroperoxydehydroabietic acid--a contact allergen in colophony from pinus species
L P Shao1, E Gäfvert, U Nilsson
1Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Stockholm, Sweden.
Phytochemistry
|March 1, 1995
Abstract:
A new hydroperoxide, 15-hydroperoxydehydroabietic acid (15-HPDA), with contact allergenic properties has been detected in rosin obtained from Pinus species. Detection was facilitated using a synthetic preparation of 15-HPDA for reference purposes. The synthesis and the detection (HPLC and GC) of 15-HPDA in rosin are described. The allergenic activity of 15-HPDA was studied in an experimental sensitization test on guinea-pigs.