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Malignant hyperthermia susceptibility without central core disease (CCD) in a family where CCD is diagnosed
G Islander1, K G Henriksson, E Ranklev-Twetman
1Department of Anaesthesiology, University Hospital, Lund, Sweden.
Neuromuscular Disorders : NMD
|March 1, 1995
Abstract:
Central Core Disease (CCD) is a myopathy closely linked to malignant hyperthermia (MH) susceptibility. We present a family with a girl suffering from CCD. Due to the CCD diagnosis, all available relatives were investigated for MH-susceptibility. No other family member has CCD. In vitro contracture tests revealed that several relatives are MH-susceptible. Thus our results suggest that healthy members of families with CCD could be at risk for being malignant hyperthermia susceptible.