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Adenovirus and adeno-associated virus mediated gene transfer
1Laboratoire de Génétique de Virus Oncogènes, Institut Gustave Roussy, Villejuif, France.
British Medical Bulletin
|January 1, 1995
Abstract:
In this review we describe current strategies for adenoviral mediated gene transfer (AMGT) and adeno-associated viral mediated gene transfer (AAVMGT). We consider the structure and molecular biology of adenoviruses and adeno-associated viruses and detail the current advantages and disadvantages of AMGT and AAVMGT. Potential solutions to some of the specific drawbacks to AMGT, including the development of new vectors, addition of gp19k, organoides, and the use of non-human adenoviral vectors, are discussed.