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Herpes virus-based vectors

S Efstathiou1, A C Minson

  • 1Department of Pathology, University of Cambridge, UK.

British Medical Bulletin
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Herpes simplex virus (HSV) shows potential as a gene delivery vehicle for lifelong latent infections. Further research in animal models is needed to define long-term gene expression from latent HSV genomes in various cell types.

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Area of Science:

  • Virology
  • Gene Therapy
  • Neuroscience

Background:

  • Herpesviruses are large DNA viruses capable of lifelong latent infections.
  • Herpes simplex virus (HSV) is a potential gene delivery vehicle due to its natural latency in neurons.
  • Current research has primarily focused on HSV for gene delivery applications.

Purpose of the Study:

  • To explore the potential of herpesviruses, particularly HSV, as gene delivery vehicles.
  • To review the current state of HSV-mediated gene delivery in vitro and in vivo.
  • To identify future research directions for HSV-based gene therapy.

Main Methods:

  • Review of existing literature on herpesvirus and HSV gene delivery.
  • Analysis of studies demonstrating reporter gene delivery using HSV vectors (replication competent and defective).

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  • Examination of research on physiological modifications in the central nervous system (CNS) via HSV gene delivery.

    • Main Results:

    • HSV has been successfully used to deliver reporter genes both in vitro and in vivo.
    • Significant physiological modifications in the CNS have been achieved using HSV-mediated gene delivery.
    • Replication competent and defective HSV vectors have been employed for gene delivery.

    Conclusions:

    • HSV holds promise as a gene delivery vector for establishing latent infections.
    • Further investigation using animal models is crucial to optimize HSV-mediated gene therapy.
    • Defining the requirements for long-term gene expression from latent HSV genomes in diverse cell types in vivo is essential.