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Related Experiment Videos

Screening for thyroid disease at the menopausal clinic

M Faughnan1, R Lepage, P Fugère

  • 1Centre de recherche clinique André-Viallet, Hôpital Saint-Luc, Montréal, Québec.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|February 1, 1995
PubMed
Summary

Routine thyroid screening in women at menopausal clinics is recommended. The study found 10% of women had abnormal thyroid stimulating hormone (TSH) levels, indicating a high prevalence of thyroid dysfunction in this population.

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Area of Science:

  • Endocrinology
  • Women's Health
  • Geriatrics

Background:

  • Hypothyroidism prevalence increases with age, affecting up to 10% of older women.
  • The study focuses on aging women attending their first menopausal clinic consultation.

Purpose of the Study:

  • To determine if routine thyroid disease screening is justified in women attending a menopausal clinic.
  • To assess the prevalence of thyroid dysfunction in this specific demographic.

Main Methods:

  • 500 consecutive patients at a menopausal clinic underwent standard thyroid profiles (Total T4, T3 uptake, FTI, TSH) and antibody testing.
  • A reference group of 23 age-matched peri-menopausal women underwent TRH response testing.

Main Results:

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  • 13 women (2.6%) had diagnosed hypothyroidism, with 4 undertreated.
  • 50 subjects (10%) had abnormal TSH levels: 3 hyperthyroid (0.6%), 8 overtly hypothyroid (1.6%).
  • 12 subjects (2.4%) had sub-clinical hypothyroidism, identified by TRH testing, goiter, and positive antibody titers.

    • Conclusions:

    • A significant number of women attending menopausal clinics have undiagnosed or undertreated thyroid disease.
    • Routine thyroid screening in this population is warranted due to the high prevalence of hypothyroidism.
    • Sub-clinical hypothyroidism is also prevalent and may benefit from further investigation and management.