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Debrisoquine hydroxylation in a Polish population
P K Kunicki1, D Sitkiewicz, A Pawlik
1Department of Clinical Biochemistry, National Institute of Cardiology, Warszawa, Poland.
European Journal of Clinical Pharmacology
|January 1, 1995
Abstract:
The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR > 12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.