[Electrophoretic profile of proteinuria in normal pregnancy and in gestational hypertension]

The aim of this study was the determination of the electrophoretic patterns and evaluation of the proteinuria type in the normal pregnancy and in women with gestational hypertension with or without pathological proteinuria, using high performance electrophoresis in SDS-polyacrylamide as analytical tool. The study was done with patients from the General Hospital of the Ministry of Health in Durango, México. Three groups were formed; one included normal pregnant women (n = 13); the second one was formed by patients with gestational hypertension without pathological proteinuria (n = 25); the third group was formed by patients with gestational hypertension and pathological proteinuria (n = 12). The electrophoretic pattern in the three groups showed high and low molecular weight proteins, corresponding to mixed proteinuria (glomerular and tubular). The samples from the group of hypertension of pregnancy with pathological proteinuria showed greater IgG and transferrin content. It is concluded that physiological proteinuria in the normal pregnancy and pathological proteinuria in gestational hypertension differ quantitatively in an absolute and relative manner. The analytical method employed in this study is useful in the evaluation of renal compromise in diseases coursing with proteinuria.