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Related Experiment Videos

Resting asynchronous left ventricular contraction abnormality analyzed by a phase method in spastic angina pectoris

J Wu1, T Takeda, H Toyama

  • 1Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|June 1, 1995
PubMed
Summary

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Quantitative phase analysis reveals asynchronous left ventricular (LV) contraction in patients with spastic angina pectoris at rest. This asynchrony correlates with reduced ejection fraction during stress, aiding in diagnosing silent ischemia.

Area of Science:

  • Cardiology
  • Nuclear Cardiology
  • Cardiac Imaging

Background:

  • Spastic angina pectoris can present with silent ischemia and myocardial stunning.
  • Left ventricular (LV) wall motion abnormalities are key indicators of cardiac dysfunction.

Purpose of the Study:

  • To investigate left ventricular (LV) wall motion abnormalities using quantitative phase analysis in patients with spastic angina pectoris.
  • To assess LV asynchrony during rest and hyperventilation stress testing.

Main Methods:

  • Equilibrium radionuclide ventriculography (ERNV) and phase analysis were performed on 36 patients with spastic angina and 13 controls.
  • First-pass methodology and hyperventilation stress testing were used to induce and assess spasm.
  • LV asynchrony was evaluated by analyzing the standard deviation (s.d.) of LV phase distribution at rest.

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Main Results:

  • Patients with spastic angina exhibited significantly greater LV phase distribution s.d. at rest compared to controls (11.28° ± 1.79° and 10.02° ± 1.57° vs. 6.16° ± 1.07°).
  • A linear correlation was observed between resting LV phase distribution s.d. and the percentage decrease in ejection fraction during hyperventilation stress.
  • Asynchronous LV contraction was detected at rest in spastic angina patients, even without significant hypokinesis.

Conclusions:

  • Resting quantitative phase analysis effectively detects asynchronous LV contraction in spastic angina pectoris.
  • The degree of LV asynchrony correlates with impaired ejection fraction during stress, suggesting its utility in evaluating silent ischemia.
  • Phase analysis of LV phase distribution provides valuable insights into LV asynchrony in spastic angina.