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Related Experiment Videos

Male pattern alopecia a histopathologic and histochemical study

A Lattanand, W C Johnson

    Journal of Cutaneous Pathology
    |January 1, 1975
    PubMed
    Summary

    Male pattern alopecia involves miniature follicles, enlarged glands, and dermal changes. Histochemical analysis revealed no significant enzyme abnormalities, only altered vascular and nerve supply to miniature follicles.

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    Area of Science:

    • Dermatology
    • Histopathology

    Background:

    • Male pattern alopecia, also known as androgenetic alopecia, is a common condition.
    • Understanding the histological characteristics is crucial for diagnosis and potential treatments.

    Purpose of the Study:

    • To investigate the characteristic histological features of male pattern alopecia.
    • To perform histochemical analysis of tissue specimens to identify potential biochemical alterations.

    Main Methods:

    • Examination of 347 tissue specimens from 23 patients diagnosed with male pattern alopecia.
    • Histochemical staining for glycogen, acid mucosaccharides, inorganic substances, and various enzymes.
    • Assessment of vascular and nerve supply to hair follicles.

    Main Results:

    • Key features observed include miniature/vellus follicles, enlarged sebaceous glands and arrectores pilorum muscles, connective tissue streamers, and dermal thinning.
    • A mild perivascular mononuclear cell infiltrate and capillary dilatation were sometimes present.
    • An increased number of mast cells was a frequent finding.
    • Histochemical studies showed no significant enzyme abnormalities, but did reveal altered vascular and nerve supply to miniature follicles.

    Conclusions:

    • Male pattern alopecia is characterized by specific follicular and dermal changes.
    • While enzyme activity appears normal, alterations in vascular and nerve supply to miniaturized follicles are implicated.

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