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Related Experiment Videos

Omeprazole and dry mouth

J P Teare1, C Spedding, M W Whitehead

  • 1Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London, UK.

Scandinavian Journal of Gastroenterology
|March 1, 1995
PubMed
Summary

Omeprazole therapy can reduce salivary flow, potentially leading to dry mouth. This condition may increase the risk of oral infections, especially in edentulous patients.

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Oral Medicine

Background:

  • Omeprazole irreversibly inhibits the H+/K+-ATPase, reducing gastric acid secretion.
  • Commonly reported side effects include nausea, vomiting, diarrhea, constipation, and headache.
  • Dry mouth (xerostomia) is an underreported side effect of omeprazole therapy.

Purpose of the Study:

  • To investigate the incidence and characteristics of dry mouth in patients undergoing omeprazole treatment.
  • To assess salivary flow rates in patients experiencing dry mouth during omeprazole therapy.
  • To evaluate the potential link between reduced salivary flow and opportunistic oral infections.

Main Methods:

  • Six patients reporting dry mouth during omeprazole treatment were studied.
  • Whole salivary flow and citric acid-stimulated parotid salivary flow were measured.
  • Salivary flow rates were assessed during and after omeprazole cessation, and saliva was cultured for microbes.

Main Results:

  • Four of six patients exhibited subnormal salivary flow rates during omeprazole treatment, which normalized after cessation.
  • Three patients with the lowest salivary flows showed significant Candida albicans growth.
  • One patient also had Staphylococcus aureus growth in their saliva.

Conclusions:

  • Omeprazole treatment can lead to reduced salivary flow in some individuals.
  • The decrease in salivary flow may predispose patients to opportunistic oral infections, such as candidiasis.
  • Cessation of omeprazole therapy typically restores normal salivary function.

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