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[Clostridium difficile infection. The nosocomial aspect]

A Bucher1, G Nordbø

  • 1Medisinsk avdeling, Baerum sykehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|April 30, 1995
PubMed
Summary

Clostridium difficile infection, an antibiotic-associated nosocomial disease, is a rare but significant problem in Norway. This study investigated 22 cases, highlighting hospital-acquired infections and their clinical features.

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Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Clinical Microbiology

Background:

  • Clostridium difficile infection (CDI) is recognized as a significant cause of antibiotic-associated diarrhea.
  • While CDI is a known nosocomial problem globally, its prevalence and characteristics in Norway have been less frequently discussed.
  • Understanding the epidemiology and clinical presentation of CDI is crucial for effective hospital infection control.

Purpose of the Study:

  • To describe the clinical characteristics of Clostridium difficile infection in a Norwegian county hospital.
  • To investigate the incidence and potential sources of hospital-acquired Clostridium difficile infections within the study population.
  • To contribute to the limited data on nosocomial CDI in Norway.

Main Methods:

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  • Retrospective case series analysis of 22 patients diagnosed with Clostridium difficile infection.
  • Inclusion criteria: clinical symptoms of diarrhea and positive fecal tests for Clostridium difficile toxins A and/or B.
  • Data collection focused on patient demographics, hospitalization history, and clinical presentation.

    • Main Results:

    • A total of 22 patients with Clostridium difficile infection were identified.
    • Eleven patients were hospitalized in a specific medical ward at the time of diagnosis, suggesting a potential cluster of hospital-acquired infections.
    • An additional five patients were also presumed to have acquired the infection in the hospital setting.
    • The study discusses the nosocomial aspects and clinical features observed in the patient cohort.

    Conclusions:

    • Clostridium difficile infection represents a notable, albeit infrequently discussed, nosocomial issue in Norway.
    • A significant proportion of the identified cases were likely hospital-acquired, emphasizing the importance of infection control measures.
    • Further epidemiological studies are warranted to fully understand the burden and transmission dynamics of CDI in Norwegian healthcare settings.