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The mechanisms of DNA topoisomerases
1Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Trends in Biochemical Sciences
|April 1, 1995
Abstract:
Recent structural and mechanistic studies, as well as the discovery of new enzymes in the DNA topoisomerase family, allow these enzymes to be classified into three groups. Each group reflects the evolution of three different mechanistic strategies to manipulate DNA topology.