Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Penile Merkel cell carcinoma

S Tomic1, T F Warner, E Messing

  • 1Department of Pathology, University of Wisconsin Hospital, Madison, USA.

Urology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-inflammatory and immunomodulatory effects of Biodentine on human periapical lesion cells in culture.

International endodontic journal·2020
Same author

Timing of the definitive procedure and ileostomy closure for total colonic aganglionosis HD: Systematic review.

Journal of pediatric surgery·2020
Same author

Reply by Authors.

The Journal of urology·2019
Same author

Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity.

European journal of medicinal chemistry·2019
Same author

Efficacy and safety of TC dose-dense chemotherapy as first-line treatment of epithelial ovarian cancer: a single-institution retrospective cohort study.

Japanese journal of clinical oncology·2019
Same author

Quantum spin liquids unveil the genuine Mott state.

Nature materials·2018

Merkel cell carcinoma, a rare genital cancer, was identified in the penis frenulum. This aggressive neuroendocrine tumor presented with metastases and recurrence, marking its first documented occurrence in this location.

Area of Science:

  • Oncology
  • Urologic Oncology
  • Dermatopathology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
  • Genital MCC is exceptionally rare, previously documented only in vulvar mucosa.
  • This study focuses on an unusual presentation of MCC in the penile frenulum.

Observation:

  • A case of aggressive Merkel cell carcinoma in the frenulum of the penis is described.
  • The primary tumor was histologically associated with an adjacent squamous cell carcinoma in situ.
  • The patient experienced lymph node metastasis, local recurrence, and widespread dissemination.

Findings:

  • This report details the first instance of Merkel cell (neuroendocrine) carcinoma occurring in the penile frenulum.
  • The penile frenulum site is a novel location for this rare malignancy.

Related Experiment Videos

  • The tumor exhibited aggressive behavior with rapid metastasis and recurrence.

    • Implications:

    • This case expands the known anatomic sites for genital Merkel cell carcinoma.
    • It highlights the potential for aggressive behavior and dissemination even in rare locations.
    • Further research into penile MCC is warranted to understand its unique characteristics and treatment strategies.