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Related Experiment Videos

Partial ureteral obstruction: a new variable and reversible canine experimental model

A A Shokeir1

  • 1Urology & Nephrology Center, Mansoura University, Egypt.

Urology
|June 1, 1995
PubMed
Summary

Researchers developed a simple, reliable, and reversible experimental model for partial ureteral obstruction in dogs. This model allows for variable obstruction grades and demonstrates successful recovery of kidney function after intervention.

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Area of Science:

  • Urology
  • Experimental Surgery
  • Animal Models

Background:

  • Partial ureteral obstruction is a significant clinical condition.
  • Existing experimental models may lack simplicity, reliability, or reversibility.

Purpose of the Study:

  • To create a novel, versatile, and reproducible experimental model of partial ureteral obstruction.
  • To assess the characteristics of this new model in a canine subject.

Main Methods:

  • A 6 F ureteral catheter was modified and placed in the canine ureter, with partial obstruction created using stylets of varying diameters.
  • Three distinct obstruction grades were induced in 12 dogs.
  • Intravenous urography (IVU) and technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3) renal scans were performed before and after obstruction removal.

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Main Results:

  • The model successfully produced three grades of hydroureteronephrosis, correlating with stylet diameter.
  • Post-intervention imaging and functional scans showed significant improvement in the obstructed renoureteral units.
  • The obstruction was confirmed to be reversible following catheter removal and ureteroneocystostomy.

Conclusions:

  • The developed experimental model is simple, reliable, variable, and reversible.
  • This model is suitable for studying the effects and potential treatments of partial ureteral obstruction.
  • The canine model provides a valuable platform for advancing research in urologic obstruction.