Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Functional capacity after cardiac transplantation]

A Cohen-Solal1, B Ferron, Y Pansard

  • 1Service de cardiologie, hôpital Beaujon, Clichy.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|October 1, 1994
PubMed
Summary

Heart transplant recipients often have poor exercise tolerance due to cardiac denervation, diastolic dysfunction, and muscle abnormalities. Addressing these factors is crucial for improving long-term outcomes in cardiac failure patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment.

European heart journal. Quality of care & clinical outcomes·2022
Same author

Inflammation versus mechanical stretch biomarkers over time in acutely decompensated heart failure with reduced ejection fraction.

International journal of cardiology·2016
Same author

Trends in death attributed to myocardial infarction, heart failure and pulmonary embolism in Europe and Canada over the last decade.

QJM : monthly journal of the Association of Physicians·2014
Same author

Unusual pseudotumoral right atrial involvement in Listeria monocytogenes septicemia.

Circulation·2012
Same author

Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors: recommendations from the EACPR. Part II.

European journal of preventive cardiology·2012
Same author

Use of tamoxifen in a German shepherd dog with sclerosing encapsulating peritonitis.

The Journal of small animal practice·2010

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Exercise Physiology

Context:

  • Cardiac transplantation significantly improves survival for patients with severe heart failure (NYHA Class IV).
  • Despite successful transplantation, many patients experience prolonged poor exercise tolerance.
  • Understanding the multifactorial causes of reduced exercise capacity post-transplant is critical.

Purpose:

  • To elucidate the primary reasons behind the persistent poor exercise tolerance in cardiac transplant recipients.
  • To identify the key physiological impairments affecting functional capacity after heart transplantation.

Summary:

  • Cardiac denervation, resulting from the surgical procedure, impairs the heart's ability to increase rate (chronotropic reserve).
  • Diastolic left ventricular dysfunction contributes to impaired relaxation and filling of the transplanted heart.

Related Experiment Videos

  • Intrinsic myocardial abnormalities, exacerbated by deconditioning and immunosuppressive therapy, further limit exercise capacity.

    • Impact:

    • This research highlights the need for targeted rehabilitation strategies in heart transplant recipients.
    • Identifying these limitations can guide the development of interventions to enhance functional recovery and quality of life.
    • Improved understanding may lead to optimized post-transplant management protocols.