Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of the pentraxins

H Gewurz1, X H Zhang, T F Lint

  • 1Department of Immunology/Microbiology, Rush Medical College, Chicago, Il 60612, USA.

Current Opinion in Immunology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[An outbreak of paratyphoid fever in a county of Yunnan province, 2010-2011].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2017
Same author

[Prognostic significance of early assessment of minimal residual disease in acute myeloid leukemia with mutated NPM1 patients].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2017
Same author

Fe-based metallic glass catalyst with nanoporous surface for azo dye degradation.

Chemosphere·2017
Same author

[Eltrombopag for refractory thrombocytopenia in patients with allogeneic hematopoietic stem cell transplantation].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2017
Same author

Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia.

Bone marrow transplantation·2016
Same author

Genome-wide identification, phylogenetic relationships, and expression analysis of the carotenoid cleavage oxygenase gene family in pepper.

Genetics and molecular research : GMR·2016
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

The serum amyloid P component

Area of Science:

  • Structural Biology
  • Immunology

Background:

  • Serum amyloid P component (SAP) is a key member of the pentraxin family.
  • Understanding SAP structure is crucial for elucidating its biological roles.

Purpose of the Study:

  • To determine the three-dimensional structure of serum amyloid P component.
  • To identify functional binding sites within SAP.
  • To explore evolutionary and functional aspects of pentraxins.

Main Methods:

  • X-ray diffraction was used to visualize the SAP structure.
  • Bioinformatic analyses were performed on related proteins.

Main Results:

  • The first 3D structure of a pentraxin, SAP, was determined.
  • Identified binding sites for calcium, ligands, and complement.

Related Experiment Videos

  • Described novel fusion proteins homologous to pentraxins.

    • Conclusions:

    • The determined structure provides a foundation for understanding SAP function.
    • New insights into pentraxin evolution, function, and interactions were gained.
    • This work advances the study of pentraxin-related biological processes.