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Updated: Aug 19, 2026

Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia
Published on: November 17, 2014
The effect of intradermal corticosteroids on skin flap edema
1Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston, USA.
Objective:
To validate a model for skin flap edema in the piglet and determine whether intraoperative and postoperative intradermal corticosteroids reduce the edema created.
Design:
Prospective, randomized, matched-control animal model.
Setting:
Animal laboratory.
Participants:
Twenty-five weight-matched purebred Yorkshire piglets.
Intervention:
Intraoperative and postoperative injections of intradermal triamcinolone.
Main Outcome Measured:
Flap edema.
Results:
A reproducible skin flap edema model was validated in the piglet. Intraoperative intradermal corticosteroids decreased flap edema but postoperative corticosteroids did not.
Conclusion:
Clinical improvement in skin flap and supratip fullness may result from mechanisms other than edema.
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