Related Experiment Videos
Clear cell odontogenic carcinoma. A clinicopathologic analysis
L R Eversole1, D C Duffey, N B Powell
1Department of Oral and Maxillofacial Pathology, University of California-Los Angeles School of Dentistry, USA.
Archives of Otolaryngology--Head & Neck Surgery
|June 1, 1995
Summary
Clear cell odontogenic tumor, a rare jaw neoplasm, is aggressive and prone to local recurrence and distant metastasis. Due to its malignant nature, it should be termed clear cell odontogenic carcinoma.
Area of Science:
- Oral pathology
- Oncology
Background:
- Clear cell odontogenic tumor (CCOT) is a rare jaw neoplasm.
- Histologically, CCOT can be misdiagnosed as metastatic renal cell carcinoma.
- CCOT exhibits aggressive behavior.
Purpose of the Study:
- To review cases of clear cell odontogenic tumor.
- To determine the clinical and pathological characteristics of CCOT.
- To establish the appropriate classification and management of CCOT.
Main Methods:
- Retrospective review of 17 cases of clear cell odontogenic tumor.
- Analysis of histological features, clinical presentation, and treatment outcomes.
Main Results:
- Seventy percent of CCOT cases occurred in the mandible.
- Tumors presented as poorly marginated radiolucencies.
- CCOT demonstrated a high rate of local recurrence and distant metastasis.
- A marked female predilection was observed, with most cases diagnosed between the fifth and seventh decades of life.
Conclusions:
- Clear cell odontogenic tumor is a malignant entity.
- The term clear cell odontogenic carcinoma is proposed.
- Aggressive surgical management is recommended for clear cell odontogenic carcinoma.