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Biodegradable polymers as biomaterials

¹Chemical Engineering Department, Hacettepe University, Ankara, Turkey.

Journal of Biomaterials Science. Polymer Edition

|January 1, 1995

Summary

Biomaterials, particularly polymers, are crucial for medical devices and prostheses. Research focuses on developing novel, biocompatible, and bioresponsive polymers for improved in vivo performance and controlled degradation.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Biomaterials, especially polymers, are essential for prostheses and medical devices.
Key requirements include biocompatibility and adherence to regulatory standards.
Polymers can be nondegradable or designed for controlled in vivo degradation.

Purpose of the Study:

To review the criteria and requirements for biomaterials in medical applications.
To discuss the degradation mechanisms of polymers, including hydrolytic and enzymatic degradation.
To highlight the trend towards synthesizing novel polymers with enhanced biocompatibility and bioresponsiveness.

Main Methods:

Literature review of current biomaterial applications and research trends.
Analysis of polymer degradation mechanisms (hydrolytic and enzymatic).
Discussion of natural and synthetic biodegradable polymers in biomedical use.

Main Results:

Polymers represent the most diverse class of biomaterials.
Hydrolytic degradation, potentially involving enzymes, is a primary in vivo degradation pathway.
Current polymers and processing methods require enhancement for optimal biological performance.

Conclusions:

There is a significant need for improved polymers and processing techniques in biomedical applications.
The synthesis of novel polymers with enhanced biocompatibility and bioresponsiveness is a key research direction.
Advancements in polymer design are critical for future medical device development.

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