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Genomic organization of human histo-blood group ABO genes
F Yamamoto1, P D McNeill, S Hakomori
1Department of Molecular Biology, Biomembrane Institute, Seattle, WA 98119, USA.
Glycobiology
|February 1, 1995
Abstract:
We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined. The human ABO genes consist of at least seven exons, and the coding sequence in the seven coding exons spans over 18 kb of the genomic DNA. The exons range in size from 28 to 688 bp, with most of the coding sequence lying in exon 7.