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Biotransformation of diphenyl ether by the yeast Trichosporon beigelii SBUG 752
F Schauer1, K Henning, H Pscheidl
1Institut f. Mikrobiologie, Ernst-Moritz-Arndt-Universität, Germany.
Biodegradation
|June 1, 1995
Abstract:
Trichosporon beigelii SBUG 752 was able to transform diphenyl ether. By TLC, HPLC, GC, GC-MS, NMR- and UV-spectroscopy, several oxidation products were identified. The primary attack was initiated by a monooxygenation step, resulting in the formation of 4-hydroxydiphenyl ether, 2-hydroxydiphenyl ether and 3-hydroxydiphenyl ether (48:47:5). Further oxidation led to 3,4-dihydroxydiphenyl ether. As a characteristic product resulting from the cleavage of an aromatic ring, the lactone of 2-hydroxy-4-phenoxymuconic acid was identified. The possible mechanism of ring cleavage to yield this metabolite is discussed.