Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of layers, maps and modules

A Gierer1, C M Müller

  • 1Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.

Current Opinion in Neurobiology
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenging behaviour in students with intellectual disabilities: the role of individual and classmates' communication skills.

Journal of intellectual disability research : JIDR·2022
Same author

Genotypic and phenotypic distinctness of restored and indigenous populations of Pimpinella saxifraga L. 8 or more years after restoration.

Plant biology (Stuttgart, Germany)·2020
Same author

Quantitative analysis of cell types during growth and morphogenesis in Hydra.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen·2017
Same author

Model for DNA and protein interactions and the function of the operator.

Nature·2010
Same author

[57-year-old patient with systemic inflammatory response syndrome].

Deutsche medizinische Wochenschrift (1946)·2009
Same author

Pathology associated with sporadic Parkinson's disease--where does it end?

Journal of neural transmission. Supplementum·2006

Developing neurons gain unique features based on their position. Molecular gradients and neural activity guide axonal growth and map formation in the brain.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Neuronal cell sheets develop position-specific features.
  • Axonal growth and targeting rely on guiding cues for map formation.
  • Molecular gradients and neural activity influence neuronal organization.

Purpose of the Study:

  • To explore mechanisms underlying position-specific feature acquisition in developing neuronal cell sheets.
  • To understand the roles of molecular gradients and activity-dependent processes in neuronal development.

Main Methods:

  • Investigating mechanisms of feature acquisition in radial and tangential dimensions.
  • Analyzing the involvement of graded molecular distributions in growth cone navigation and axonal branching.
  • Examining activity-dependent processes in functional architecture and modular organization.

Related Experiment Videos

Main Results:

  • Mechanisms for acquiring position-specific features differ between radial and tangential dimensions.
  • Graded molecular distributions are implicated in growth cone navigation and axonal branching.
  • Activity-dependent processes significantly shape functional architecture and modular organization.

Conclusions:

  • Position-specific features in developing neurons are established through distinct radial and tangential mechanisms.
  • Molecular gradients and neural activity are crucial for guiding axonal development and establishing functional neural maps.