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HIV retrotransposon activity and the immunopathogenesis of AIDS
E J Johnson1, R C Sizemore, A A Gottlieb
1Dept of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112-2699, USA.
Trends in Microbiology
|March 1, 1995
Abstract:
This article presents the new hypothesis that HIV retrotransposon insertional mutagenesis induces genomic effects that bring about immune dysfunction through disruption, deletion or rearrangement of the genome of the host. This activity may be augmented by the action of most, if not all, the cofactors of HIV-induced disease.